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Page menu: --- Publications --- Software --- Presentations --- |
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Publications
- See also my profile at Google Scholar Citations |
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In press: |
Lenz TL (In press) HLA genes - A hallmark of functional genetic variation and complex evolution. In Boegel S (Ed.). HLA Typing 2nd Edition: Methods and Protocols. Springer. |
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Efstratiou A, Gaigher A, Künzel S, Teles A, Lenz TL (Online early) Template-specific optimization of NGS genotyping pipelines reveals allele-specific variation in MHC gene expression. Molecular Ecology Resources. |
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2024 |
Pietsch E, Niedermüller K, Andrews M, Meyer BS, Lenz TL, Wilson DW, Gilberger T-W, Burda P-C (2024) Disruption of a Plasmodium falciparum patatin-like phospholipase delays male gametocyte exflagellation. Molecular Microbiology. 121: 529-542 |
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Krishna C, Tervi A, Saffern M, Wilson EA, Yoo S-K, Mars N, Roudko V, Byuri AC, Jones SE, Vaninov N, Selvan ME, Gümüs ZH, FinnGen, Lenz TL, Merad M, Boffetta P, Martinez-Jimenez F, Ollila HM, Samstein RM, Chowell D (2024) Immunogenetic basis for lung cancer risk. Science 383: eadi3808. |
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2023: |
Osei-Wusu S, Tetteh JKA, Musah AB, Ntiamoah DO, Arthur N, Adjei A, Arbues A, Ofori EA, Mensah KA, Galevo SEA, Frempong AF, Asare P, Asante-Poku A, Otchere ID, Kusi KA, Lenz TL, Gagneux S, Portevin D and Yeboah-Manu D (2023) Macrophage susceptibility to infection by Ghanaian Mycobacterium tuberculosis complex lineages 4 and 5 varies with self-reported ethnicity. Frontiers in Cellular and Infection Microbiology 13: 1163993. |
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COVID-19 Host Genetics Initiative (2023) A second update on mapping the human genetic architecture of COVID-19. Nature 621: E7-E26. |
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Thorburn D-MJ, Sagonas K, Binzer-Panchal M, Chain FJJ, Feulner PGD, Bornberg-Bauer E, Reusch TBH, Samonte-Padilla IE, Milinski M, Lenz TL, Eizaguirre C (2023) Origin Matters: Using a Local Reference Genome Improves Measures in Population Genomics. Molecular Ecology Resources 23: 1706-1723. |
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Sakaue S, Gurajala S, Curtis M, Luo Y, Choi W, Ishigaki K, Kang JB, Rumker L, Deutsch AJ, Schönherr S, Lukas Forer L, LeFaive J, Fuchsberger C, Han B, Lenz TL, de Bakker PIW, Okada Y, Smith AV, Raychaudhuri S (2023) A statistical genetics guide to identifying HLA alleles driving complex disease. Nature Protocols 18: 2625-2641. |
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Abel C, Giertz P, Ratovonamana YR, Püttker T, Rakotondranary SJ, Scheel BM, Lenz TL, Ganzhorn JU (2023) Habitat quality affects the social organization in mouse lemurs (Microcebus griseorufus). Behavioral Ecology and Sociobiology 77: 65. |
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Vinkler M, Fiddaman SR, Tesický M, O'Connor EA, Savage AE, Lenz TL, Smith AL, Kaufman J, Bolnick D, Davies CS, Dedic N, Flies AS, Samblás MMG, Henschen A, Novák K, Palomar G, Raven N, Samake K, Slade J, Veetil NK, Voukali E, Höglund J, Richardson DS, Westerdahl H (2023) Understanding the evolution of immune genes in jawed vertebrates. Journal of Evolutionary Biology 36: 847-873. |
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ElAbd H, Bacher P, Tholey A, Lenz TL, Franke A (2023) Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins. Frontiers in Immunology 14: 1107266. |
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Wichers-Misterek J, Binder A, Mesén-Ramírez P, Dorner LP, Safavi S, Fuchs G, Lenz TL, Bachmann A, Wilson D, Frischknecht F, Gilberger T (2023) A microtubule associated protein is essential for malaria parasite transmission. mBio 14: e03318-22. |
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2022: |
Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Ortiz AB, Salazar A, Chercoles AG, Palom A, Ruiz A, Garcia-Fernandez A, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti A, Aghemo A, Gerussi A, Ramirez A, Braun A, Nebel A, Barreira A, Lleo A, Teles A, Kildal AB, Biondi A, Caballero-Garralda A, Ganna A, Gori A, Glück A, Lind A, Tanck A, Hinney A, Nolla AC, Fracanzani AL, Peschuck A, Cavallero A, Dyrhol-Riise AM, Ruello A, Juliŕ A, Muscatello A, Pesenti A, Voza A, Rando-Segura A, Solier A, Schmidt A, Cortes B, Mateos B, Nafria-Jimenez B, Schaefer B, Jensen B, Bellinghausen C, Maj C, Ferrando C, Horra C, Quereda C, Skurk C, Thibeault C, Scollo C, Herr C, Spinner CD, Gassner C, Lange C, Hu C, Paccapelo C, Lehmann C, Angelini C, Cappadona C, Azuure C, COVICAT study group, Aachen Study (COVAS), Bianco C, Cea C, Sancho C, Hoff DAL, Galimberti D, Prati D, Haschka D, Jiménez D, Pestańa D, Toapanta D, Muńiz-Diaz E, Azzolini E, Sandoval E, Binatti E, Scarpini E, Helbig ET, Casalone E, Urrechaga E, Paraboschi EM, Pontali E, Reverter E, Calderón EJ, Navas E, Solligĺrd E, Contro E, Arana-Arri E, Aziz F, Garcia F, Sánchez FG, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Kurth F, Blasi F, Malvestiti F, Medrano FJ, Mesonero F, Rodriguez-Frias F, Hanses F, Müller F, Hemmrich-Stanisak G, Bellani G, Grasselli G, Pezzoli G, Costantino G, Albano G, Cardamone G, Bellelli G, Citerio G, Foti G, Lamorte G, Matullo G, Baselli G, Kurihara H, Neb H, My I, Kurth I, Hernández I, Pink I, Rojas I, Galván-Femenia I, Holter JC, Afset JE, Heyckendorf J, Kässens J, Damĺs JK, Rybniker J, Altmüller J, Ampuero J, Martín J, Erdmann J, Banales JM, Badia JR, Dopazo J, Schneider J, Bergan J, Barretina J, Walter J, Quero JH, Goikoetxea J, Delgado J, Guerrero JM, Fazaal J, Kraft J, Schröder J, Risnes K, Banasik K, Müller KE, Gaede KI, Garcia-Etxebarria K, Tonby K, Heggelund L, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Sander LE, Lippert LJ, Terranova L, Nkambule L, Knopp L, Gustad LT, Garbarino L, Santoro L, Téllez L, Roade L, Ostadreza M, Intxausti M, Kogevinas M, Riveiro-Barciela M, Berger MM, Schaefer M, Niemi MEK, Gutiérrez-Stampa MA, Carrabba M, Basso MEF, Valsecchi MG, Hernandez-Tejero M, Vehreschild MJGT, Manunta M, Acosta-Herrera M, D'Angiň M, Baldini M, Cazzaniga M, Grimsrud MM, Cornberg M, Nöthen MM, Marquié M, Castoldi M, Cordioli M, Cecconi M, D'Amato M, Augustin M, Tomasi M, Boada M, Dreher M, Seilmaier MJ, Joannidis M, Wittig M, Mazzocco M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Ayo NI, Blay N, Chueca N, Montano N, Braun N, Ludwig N, Marx N, Martínez N, Norwegian SARS-CoV-2 Study group, Cornely OA, Witzke O, Palmieri O, Group PS, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, Espańa PP, Hoffmann P, Rosenstiel P, Schommers P, Suwalski P, Pablo R, Ferrer R, Bals R, Gualtierotti R, Gallego-Durán R, Nieto R, Carpani R, Morilla R, Badalamenti S, Haider S, Ciesek S, May S, Bombace S, Marsal S, Pigazzini S, Klein S, Pelusi S, Wilfling S, Bosari S, Volland S, Brunak S, Raychaudhuri S, Schreiber S, Heilmann-Heimbach S, Aliberti S, Ripke S, Dudman S, Wesse T, Zheng T, The STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force, Bahmer T, Eggermann T, Illig T, Brenner T, Pumarola T, Feldt T, Folseraas T, Cejudo TG, Landmesser U, Protzer U, Hehr U, Rimoldi V, Monzani V, Skogen V, Keitel V, Kopfnagel V, Friaza V, Andrade V, Moreno V, Albrecht W, Peter W, Poller W, Farre X, Yi X, Wang X, Khodamoradi Y, Karadeniz Z, Latiano A, Goerg S, Bacher P, Koehler P, Tran F, Zoller H, Schulte EC, Heidecker B, Ludwig KU, Fernández J, Romero-Gómez M, Albillos A, Invernizzi P, Buti M, Duga S, Bujanda L, Hov JR*, Lenz TL*, Asselta R*, de Cid R*, Valenti L*, Karlsen TH*, Cáceres M*, Franke A* (2022) Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics 31: 3945-3966. |
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Huang W, Wang X, Liu B, Lenz TL, Peng Y, Dong L, Zhang Y (2022) Evaluation of genetic diversity and parasite-mediated selection of MHC class I genes in Emberiza godlewskii (Passeriformes: Emberizidae). Diversity 14: 925. |
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Tebbe J, Ottensmann M, Havenstein K, Efstratiou A, Lenz TL, Caspers BA., Forcada J, Tiedemann R, Hoffman JI (2022) Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals. Scientific Reports 12: 17933. |
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Pagliuca S, Gurnari C, Rubio MT, Visconte V, Lenz TL (2022) Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond. Frontiers in Immunology 13: 944872. |
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Chowell D, Yoo S-K, Valero C, Pastore A, Krishna C, Lee M, Hoen D, Shi H, Kelly DW, Patel N, Makarov V, Ma X, Vuong L, Sabio EY, Weiss K, Kuo F, Lenz TL, Samstein RM, Riaz N, Adusumilli PS, Balachandran VP, Plitas G, Hakimi AA, Abdel-Wahab O, Shoushtari AN, Postow MA, Motzer RJ, Ladanyi M, Zehir A, Berger MF, Gönen M, Morris LGT, Weinhold N, Chan TA (2022) An integrated clinical-genetic model for accurate prediction of immune checkpoint blockade efficacy across multiple cancer types. Nature Biotechnology 40: 499-506. |
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Purde M-T, Niederer R, Wagner NB, Diem S, Berner F, Hasan Ali O, Hillmann D, Bergamin I, Joerger M, Risch M, Niederhauser C, Lenz TL, Früh M, Risch L, Semela D, Flatz L (2022) Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients. Journal of Cancer Research and Clinical Oncology 148: 647-656. |
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2021: |
COVID-19 Host Genetics Initiative (2021) Mapping the human genetic architecture of COVID-19. Nature 600: 472-477. |
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Pagliuca S, Gurnari C, Awada H, Kishtagari A, Kongkiatkamon S, Terkawi L, Zawit M, Guan Y, LaFramboise T, Jha BK, Patel BJ, Hamilton BK, Majhail NS, Lundgren S, Mustjoki S, Saunthararajah Y, Visconte V, Chan T, Yang C-Y, Lenz TL, Maciejewski JP (2021) The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders. Blood 138: 2781-2798. |
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Berner F, Niederer R, Luimstra J, Pop OT, Jochum A-K, Purde M-T, Hasan Ali O, Bomze D, Bauer J, Freudenmann LK, Marcu A, Wolfschmitt E-M, Haen S, Gross T, Dubbelaar ML, Abdou M-T, Baumgartner P, MS Appenzeller C, Cicin-Sain C, Lenz TL, Speiser DE, Ludewig B, Driessen C, Jörger M, Früh M, Jochum W, Cozzio A, Rammensee H-G, Walz J, Neefjes J, Flatz L (2021) Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival. OncoImmunology 10:1. |
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El Abd H, Degenhardt F, Koudelka T, Kamps A-K, Tholey A, Bacher P, Lenz TL, Franke A, Wendorff M (2021) Immunopeptidomics toolkit library (IPTK): a Python-based modular toolbox for analyzing immunopeptidomics data. BMC Bioinformatics 22: 405. |
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Özer O, Lenz TL (2021) Unique pathogen peptidomes facilitate pathogen-specific selection and specialization of MHC alleles. Molecular Biology and Evolution 38: 4376-4387. |
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Haller M, Bonczarowska JH, Rieger D, Lenz TL, Nebel A, Krause-Kyora B (2021) Ancient DNA study in medieval Europeans shows an association between HLA-DRB1*03 and paratyphoid fever. Frontiers in Immunology 12: 2802. |
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Degenhardt F, Mayr G, Wendorff M, Boucher G, Ellinghaus E, Ellinghaus D, ElAbd H, Rosati E, Hübenthal M, Juzenas S, Abedian S, Vahedi H, Thelma BK, Yang S, Ye BD, Cheon JH, Datta LW, Daryani NE, Ellul P, Esaki M, Fuyuno Y, McGovern DPB, Haritunians T, Hong M, Juyal G, Jung ES, Kubo M, Kugathasan S, Lenz TL, Leslie S, Malekzadeh R, Midha V, Motyer A, Ng SC, Okou DT, Raychaudhuri S, Schembri J, Schreiber S, Song K, Sood A, Takahashi A, Torres EA, Umeno J, Alizadeh BZ, Weersma RK, Wong SH, Yamazaki K, Karlsen TH, Rioux JD, Brant SR, Franke A (2021) Transethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals not only shared but also ethnicity-specific disease associations. Human Molecular Genetics 30: 356-369. |
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Immel A, Pierini F, Rinne C, Meadows J, Barquera R, Szolek A, Susat J, Böhme L, Dose J, Bonczarowska J, Drummer C, Fuchs K, Ellinghaus D, Kässens JC, Furholt M, Kohlbacher O, Schade-Lindig S, Franke A, Krause J, Müller J, Lenz TL, Nebel A, Krause-Kyora B (2021) Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry. Communications Biology 4: 113. |
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Koneczny I, Yilmaz V, Lazaridis K, Tzartos J, Lenz TL, Tzartos SJ, Tüzün E, Leypoldt F (2021) Common denominators in the immunobiology of IgG4 autoimmune diseases: What do glomerulonephritis, pemphigus vulgaris, myasthenia gravis, thrombotic thrombocytopenic purpura and autoimmune encephalitis have in common? Frontiers in Immunology 11:605214. |
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2020: |
Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta RA, Grimsrud MM, Milani C, Aziz FA, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez A-E, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero-Garralda A, Gori A, Tanck A, Nolla AC, Latiano A, Fracanzani AL, Peschuck A, Juliŕ A, Pesenti A, Voza A, Jiménez D, Mateos B, Jimenez BN, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestańa D, Muńiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, Sánchez FG, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich-Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H, ElAbd H, My I, Galván-Femenia I, Martin J, Erdmann J, Ferrusquía-Acosta J, Garcia-Etxebarria K, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Terranova L, Moreira L, Santoro L, Scudeller L, Mesonero F, Roade L, Rühlemann MC, Schaefer M, Carrabba M, Riveiro-Barciela M, Basso MEF, Valsecchi MG, Hernandez-Tejero M, Acosta-Herrera M, D'Angiň M, Baldini M, Cazzaniga M, Schulzky M, Cecconi M, Wittig M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Montano N, Braun N, Sacchi N, Martínez N, Özer O, Palmieri O, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, Ortiz AB, de Cid R, Ferrer R, Gualtierotti R, Nieto R, Goerg S, Badalamenti S, Marsal S, Matullo G, Pelusi S, Juzenas S, Aliberti S, Monzani V, Moreno V, Wesse T, Lenz TL, Pumarola T, Rimoldi V, Bosari S, Albrecht W, Peter W, Romero-Gómez M, D'Amato, M, Duga S, Banales JM, Hov JR, Folseraas T, Valenti L, Franke A, Karlsen TH (2020) Genomewide association study of severe Covid-19 with respiratory failure. New England Journal of Medicine 383:1522-1534. |
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Sagonas K, Meyer BS, Kaufmann J, Lenz TL, Häsler R, Eizaguirre C (2020) Experimental parasite infection causes genome-wide changes in DNA methylation. Molecular Biology and Evolution 37: 2287-2299. |
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ElAbd H, Bromberg Y, Hoarfrost A, Lenz TL, Franke A, Wendorff M (2020) Amino Acid Encoding for Deep Learning Applications. BMC Bioinformatics 21: 235. |
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Pierini F, Nutsua M, Böhme L, Özer O, Bonczarowska J, Susat J, Franke A, Nebel A, Krause-Kyora B, Lenz TL (2020) Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations. Scientific Reports 10: 7339. |
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Radwan J, Babik W, Kaufman J, Lenz TL, Winternitz J (2020) Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics 36: 298-311. |
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Arora J, Pierini F, McLaren PJ, Carrington M, Fellay J, Lenz TL (2020) HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation. Molecular Biology and Evolution 37: 639-650. |
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2019: |
Chowell D, Krishna C, Pierini F, Makarov V, Rizvi NA, Kuo F, Morris LGT, Riaz N, Lenz TL*, Chan TA* (2019) Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine 25: 1715-1720. |
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Huang Y, Feulner PGD, Eizaguirre C, Lenz TL, Bornberg-Bauer E, Milinski M, Reusch TBH, Chain FJJ (2019) Genome-wide genotype-expression relationships reveal both copy number and single nucleotide differentiation contribute to differential gene expression between stickleback ecotypes. Genome Biology and Evolution. 11: 2344-2359. |
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Degenhardt F, Wendorff M, Wittig M, Ellinghaus E, Datta LW, Schembri J, Ng SC, Rosati E, Hübenthal M, Ellinghaus D, Jung ES, Lieb W, Abedian S, Malekzadeh R, Cheon JH, Ellul P, Sood A, Midha V, Wong SH, Schreiber S, Yamazaki K, Kubo M, Boucher G, Rioux J, Lenz TL, Brant SR, Franke A (2019) Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles. Human Molecular Genetics 28: 2078-2092. |
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Manczinger M, Boross G, Kemény L, Müller V, Lenz TL, Papp B, Pál C (2019) Pathogen diversity drives the evolution of generalist antigen presentation in human populations. PLoS Biology 17: e3000131. |
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Arora J, McLaren PJ, Chaturvedi N, Carrington M, Fellay J, Lenz TL (2019) HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. Proceedings of the National Academy of Sciences of the United States of America 116: 944-949. |
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Hasan Ali O, Berner F, Bomze D, Faessler M, Diem S, Cozzio A, Jörger M, Früh M, Driessen C, Lenz TL*, Flatz L* (2019) Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors. European Journal of Cancer 107: 8-14. |
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2018: |
Lenz TL, Hafer N, Samonte IE, Yeates S, Milinski M (2018) Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes. Evolution 72: 2478-2490. |
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Pierini F, Lenz TL (2018) Divergent allele advantage at human MHC genes: signatures of past and ongoing selection. Molecular Biology and Evolution 35: 2145-2158. |
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Krause-Kyora B, Nutsua M, Böhme L, Pierini F, Pedersen DD, Kornell S-C, Drichel D, Bonazzi M, Möbus L, Tarp P, Susat J, Bosse E, Willburger B, Schmidt AH, Sauter J, Franke A, Wittig M, Calibe A, Nothnagel M, Schreiber S, Boldsen J*, Lenz TL*, Nebel A* (2018) Ancient DNA study reveals HLA susceptibility loci for leprosy in medieval Europeans. Nature Communications 9: 1569. |
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Lenz TL (2018) Adaptive value of novel MHC immune gene variants [Invited Commentary]. Proceedings of the National Academy of Sciences of the United States of America 115: 1414-1416. |
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2017: |
Calvignac-Spencer S, Lenz TL (2017) The One Past Health workshop - Connecting ancient DNA and zoonosis research [Meeting Report]. BioEssays 39: 1700075. |
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Kaufmann J, Lenz TL, Kalbe M, Milinski M, Eizaguirre C (2017) A field reciprocal transplant experiment reveals asymmetric costs of migration between lake and river ecotypes of three-spined sticklebacks (Gasterosteus aculeatus). Journal of Evolutionary Biology 30: 938-950. |
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2016: |
Lenz TL, Spirin V, Jordan DM, Sunyaev SR (2016) Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection. Molecular Biology and Evolution 33: 2555-2564. |
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Savova V, Chun SG, Sohail M, McCole R, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA (2016) Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nature Genetics 48: 231-237. |
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Huang Y, Chain FJJ, Panchal M, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TBH, Milinski M, Feulner, PGD (2016) Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks. Molecular Ecology 25: 943-958. |
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2015: |
McLaren PJ*, Coulonges C*, Bartha I*, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro J, Mullins JI, Obel N, Poli G, Sandhu M, Schuitemaker H, Shea P, Theodorou I, Walker BD, Weintrob A, Winkler C, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PIW, Zagury J-F, Fellay J (2015) Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proceedings of the National Academy of Sciences of the United States of America 112: 14658-14663. |
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Lenz TL (2015) Transcription in space - Environmental vs. genetic effects on differential immune gene expression [Perspective]. Molecular Ecology 24: 4583-4585. |
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Lenz TL*, Deutsch AJ*, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A, Huizinga TWJ, Abecasis G, Becker J, Boeckxstaens, GE, Chen W-M, Franke A, Gladman DD, Gockel I, Gutierrez-Achury J, Martin J, Nair RP, Nöthen MM, Onengut-Gumuscu S, Rahman P, Rantapää-Dahlqvist S, Stuart PE, Tsoi LC, Van Heel DA, Worthington J, Wouters MM, Klareskog L, Elder JT, Gregersen P, Schumacher J, Rich SS, Wijmenga C, Sunyaev SR, de Bakker PIW, Raychaudhuri S (2015) Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nature Genetics 47: 1085-1090. |
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Hu X*, Deutsch AJ*, Lenz TL, Onengut-Gumuscu S, Han B, Chen W-M, Howson JM, Todd JA, de Bakker PIW, Rich SS, Raychaudhuri S (2015) Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nature Genetics 47: 898-905. |
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Feulner PGD, Chain FJJ, Panchal M, Huang Y, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TBH, Milinski M (2015) Genomics of divergence along a continuum of parapatric population differentiation. PLoS Genetics 11: e1004966. |
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Kaufmann J, Eizaguirre C, Milinski M, Lenz TL (2015) The contribution of post-copulatory mechanisms to incipient ecological speciation in sticklebacks. Biology Letters 11: 20140933. |
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2014: |
Chain FJJ, Feulner PGD, Panchal M, Eizaguirre C, Samonte IE, Kalbe M, Lenz TL, Stoll M, Bornberg-Bauer E, Milinski M, Reusch TBH (2014) Extensive copy-number variation of young genes across stickleback populations. PLoS Genetics 10: e1004830. |
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Kaufmann J, Lenz TL, Milinski M, Eizaguirre C (2014) Experimental parasite infection reveals costs and benefits of paternal effects. Ecology Letters 17: 1409-1417. |
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2013: |
Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Yim SH, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN (2013) Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii. Nature Communications 4: 2212. |
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Lenz TL, Eizaguirre C, Kalbe M, Milinski M (2013) Evaluating patterns of convergent evolution and trans-species polymorphism at MHC immunogenes in two sympatric stickleback species. Evolution 67: 2400-2412. |
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Lenz TL, Eizaguirre C, Rotter B, Kalbe M, Milinski M (2013) Exploring local immunological adaptation of two stickleback ecotypes by experimental infection and transcriptome-wide digital gene expression analysis. Molecular Ecology 22: 774-786. |
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Feulner PGD, Chain FJJ, Panchal M, Eizaguirre C, Kalbe M, Lenz TL, Mundry M, Samonte IE, Stoll M, Milinski M, Reusch TBH, Bornberg-Bauer E (2013) Genome-wide patterns of standing genetic variation in a marine population of three-spined sticklebacks. Molecular Ecology 22: 635-649. |
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2012: |
Eizaguirre C*, Lenz TL*, Kalbe M, Milinski M (2012) Divergent selection on locally adapted MHC immune genes experimentally proven in the field. Ecology Letters 15: 723-731. |
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Eizaguirre C, Lenz TL, Kalbe M, Milinski M (2012) Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations. Nature Communications 3:621. |
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2011 |
Samonte-Padilla IE, Eizaguirre C, Scharsack JP, Lenz TL, Milinski M (2011) Induction of diploid gynogenesis in an evolutionary model system, the three-spined stickleback (Gasterosteus aculeatus). BMC Developmental Biology 11: 55. |
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Lenz TL (2011) Computational prediction of MHC II-antigen binding supports divergent allele advantage and explains trans-species polymorphism. Evolution 65: 2380-2390. |
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Lenz TL (2011) Uterine selection for immunocompetent offspring [Letter]. Proceedings of the National Academy of Sciences of the United States of America 108: E253. |
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Eizaguirre C, Lenz TL, Sommerfeld RD, Harrod C, Kalbe M, Milinski M (2011) Parasite diversity, patterns of MHC II variation and olfactory based mate choice in diverging three-spined stickleback ecotypes. Evolutionary Ecology 25: 605-622. |
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2010 |
Eizaguirre C, Lenz TL (2010) Major histocompatibility complex polymorphism: dynamics and consequences of parasite-mediated local adaptation in fishes. Journal of Fish Biology 77: 2023-2047. |
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2009 |
Lenz TL, Eizaguirre C, Scharsack JP, Kalbe M, Milinski M (2009) Disentangling the role of MHC-dependent 'good genes' and 'compatible genes' in mate choice decisions of three-spined sticklebacks under semi-natural conditions. Journal of Fish Biology (special stickleback issue) 75: 2122 - 2142. |
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Lenz TL, Wells K, Pfeiffer M, Sommer S (2009) Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus). BMC Evolutionary Biology 9: 269. |
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Eizaguirre C, Yeates SE, Lenz TL, Kalbe M, Milinski M (2009) MHC-based mate choice combines good genes and maintenance of MHC polymorphism. Molecular Ecology 18: 3316-3329. |
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Lenz TL, Eizaguirre C, Becker S, Reusch TBH (2009) RSCA genotyping of MHC for high-throughput evolutionary studies in the model organism three-spined stickleback Gasterosteus aculeatus. BMC Evolutionary Biology 9: 57. |
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Eizaguirre C, Lenz TL, Traulsen A, Milinski M (2009) Speciation accelerated and stabilized by pleiotropic major histocompatibility complex immunogenes. Ecology Letters 12: 5-12. |
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2008 |
Lenz TL, Becker, S (2008) Simple approach to reduce PCR artefact formation leads to reliable genotyping of MHC and other highly polymorphic loci - implications for evolutionary analysis. Gene 427: 117-123. |
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2007 |
Urbach D, Bittner D, Lenz TL, Bernet D, Wahli T, Wedekind C (2007) Sperm velocity in an Alpine whitefish: effects of age, size, condition, fluctuating asymmetry and gonad abnormalities. Journal of Fish Biology 71: 672-683. |
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Lenz TL, Jacob A., Wedekind C (2007) Manipulating sex ratio to increase population growth: the example of the Lesser Kestrel. Animal Conservation 10: 236-244. |
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Software / Tools |
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HED web portal |
A web portal for automated calculation of HLA Evolutionary Divergence (HED) of human individuals. HED has been associated with response to cancer immunotherapy. In collaboration with the Timothy Chan Lab at MSKCC/Cleveland Clinic. |
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GranthamDist |
Package of Perl scripts for calculating amino acid sequence divergence, e.g. individual MHC allele divergence, for humans and any other species when sequence data is available. |
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TARGT pipeline |
A pipeline for Targeted Analysis of sequence Reads for GenoTyping of HLA/MHC genes and other polymorphic regions, specifically designed for low-coverage shotgun sequence data. |
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Forward Simulation |
A program to model the evolution of a population under the Wright-Fisher model, allowing for different selection scenarios and genetic architectures. |
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Presentations at Meetings / Seminars |
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2024: |
Institute seminar, Noguchi Memorial Institute for Medical Research, Accra, Ghana. 13.02. |
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2023: |
Congress of the German Society for Immunogenetics, Halle, Germany. 11.-13.10. |
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Departmental seminar, Department of Biology, Lund University, Lund, Sweden. 28.09. |
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International MHC meeting, FU Berlin, Berlin, Germany. 07.-08.09. |
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International Conference of the Society for Molecular Biology and Evolution, Ferrara, Italy. 23.-27.07. |
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40th Blankenese Conference "Evolutionary Medicine", Hamburg, Germany. 26.06. |
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Institute of Marine Ecosystem and Fishery Science, Hamburg, Germany. 09.06. |
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Springer Laboratory, Constructor University, Bremen, Germany. 14.04. |
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Symposium on T cell Antigens and Immunogenicity in Cancer, Danish Technical University, Copenhagen, Denmark. 27.01. |
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Institute of Immunology, University Clinic Hamburg-Eppendorf, Hamburg, Germany. 23.01. |
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2022: |
Conference of the American Society for Histocompatibility and Immunogenetics (ASHI), Las Vegas, USA. 24.10. |
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BIOMEDAS Retreat, Twincore Institute, Hannover, Germany. 22.06. |
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Institute of Evolution & Biodiversity, University of Münster, Germany. 17.05. |
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International Histocompatibility and Immunogenetics Workshop (IHIW), Netherlands. 13.05. |
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International MHC seminar series, FU Berlin [online]. 26.04. |
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2021: |
Norwegian Society for Immunology, Norway [online]. 30.09. |
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National Cancer Institute - IIB Branch Meeting, USA [online]. 15.09. |
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Center for Structural Systems Biology, Hamburg, Germany. 26.08. |
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2020: |
Club EvMed - Virtual Evolutionary Medicine Conversations [online]. 27.10. |
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Institute for Virology and Immunology, University Würzburg, Germany. 13.01. |
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2019: |
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. 22.10. |
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Department of Immunology, Kiel University, Germany. 08.08. |
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Centre for Ecological and Evolutionary Synthesis, University of Oslo, Norway. 06.06. |
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2018: |
Department of Biology, Lund University, Sweden. 07.12. |
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Oktoberfest Symposium 2018: Type 1 Diabetes - Stress, Immunity and the Beta Cell. Munich, Germany. 02.10. |
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International Conference of the Society for Molecular Biology and Evolution. Yokohama, Japan. 08.-12.07. |
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Seminars on Evolution, Ecology and Behaviour, Adam Mickiewicz University, Poznan, Poland. 30.05. |
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Workshop on ancient DNA techniques in zoonosis research. Robert Koch Institute, Berlin / Germany. 15.02. |
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12th Aykut Kence Evolution Conference, METU, Ankara / Turkey. 11.02. |
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2017: |
Zoological Institute, University of Basel. 09.11. |
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International Conference of the European Society for Evolutionary Biology. Groningen, Netherlands. 20.-25.08. |
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Zoological institute, Department of Biology, University of Hamburg, Germany. 28.02. |
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BRC, Hungarian Academy of Science. Szeged, Hungary. 07.02. |
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2016: |
IRI Symposium on Evolutionary Medicine. Berlin, Germany. 10.11. |
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Annual meeting of the German Zoological Society. Kiel, Germany. 14.-17.09. |
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Max Planck Institute for the Science of Human History, Jena, Germany. 30.03. |
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German American Frontiers of Science (GAFOS-Kavli) meeting, US National Academy of Science / Humboldt Foundation, Potsdam, Germany. 10.-13.03. |
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Institute for Neuro- and Bioinformatics, University of Luebeck, Germany. 05.02. |
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Bioinformatics Network, University of Kiel, Germany. 15.01. |
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2015: |
Annual Conference of the German Society for Immunogenetics. Luebeck, Germany. 8.-10.10. |
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International Conference of the Society for Molecular Biology and Evolution. Vienna, Austria. 12.-16.07. |
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Zoological institute, Department of Biology, Hamburg University, Germany. 18.06. |
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Department of Biology, Lund University, Sweden. 12.06. |
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Inaugural meeting of the International Society for Evolution, Medicine and Public Health. Tempe, USA. 18.-21.03. |
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Department of Animal Ecology and EBC Graduate School, Uppsala University, Sweden. 17.02. |
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Department of Animal Behavior, University of Bielefeld, Germany. 14.01. |
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2014: |
Jacques Monod Conference 'Infectious diseases as drivers of evolution: the challenge ahead'. Roscoff, France. 06.-10.09. |
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2013: |
International Conference of the Society for
Molecular Biology and Evolution. Chicago, USA. 07.-11.07. |
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2012: |
Evolutionary Genomics Supergroup Retreat. Broad
Institute, Cambridge, USA. 07.12. |
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Annual meeting of the American Society of Human
Genetics. San Francisco, USA. 06.-10.11. |
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Nature Genetics Conference on Genomics of Common
Diseases. Bethesda, USA. 19.-22.09. |
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Department of Ecology and
Evolution. Stony Brook University. New York, USA. 25.04. |
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2011: |
Aquavit Symposium. MPI for Evolutionary
Biology, Plön, Germany. 30.3.-01.04. |
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2010: |
International Conference of the Society for
Molecular Biology and Evolution. Lyon, France. 04.-08.07. |
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Aquavit Symposium. MPI for Evolutionary
Biology, Plön, Germany. 14.-15.05. |
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2009: |
International Conference on Evolutionary Ecology
of Fishes. Erkner, Germany. 22.-25.11. |
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Workshop 'Mind the gap: Joining theoretical and
empirical populations genetics'. Freiburg, Germany. 02.-03.10. |
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International Conference of the European Society for
Evolutionary Biology. Torino, Italy. 24.-29.08. |
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International Conference on Stickleback
Behaviour and Evolution. Leicester, UK, 13.-17.07. |
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Aquavit Symposium. MPI for Evolutionary
Biology, Plön, Germany. 14.-15.05. |
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Workshop of the German Genetics Society.
Evolutionary Genetics: Impact of Next Generation Sequencing
Technologies. Wittenberg, Germany, 02.-04.04. |
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2008: |
Aquavit Symposium. MPI for Evolutionary
Biology, Plön, Germany. 22.-23.05. |
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PhD workshop of the German Zoological Society.
University of Hamburg, Germany. 22.-24.02. |
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2007: |
International Conference of the European Society for
Evolutionary Biology. Uppsala, Sweden. 20.-25.08. |
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Group of Prof. C. Wedekind,
Department of Ecology and Evolution, University of Lausanne,
Switzerland. 30.05. |
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Aquavit Symposium. MPI for Limnology, Plön,
Germany. 08.-09.03. |
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2006: |
International Conference on Stickleback
Behavior and Evolution. UAA, Anchorage, USA. 30.07.-04.08.06. |
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Aquavit Symposium. MPI for Limnology, Plön,
Germany. 07.-08.03. |
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PhD workshop of the German Zoological Society:
University of Potsdam, Germany. 24.-26.02. |
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2005: |
International Conference of the European Society for
Evolutionary Biology. Krakow, Poland. 15.-20.08.
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