Publications - See also my profile at Google Scholar Citations:

In press:


Kaufmann J, Lenz TL, Kalbe M, Milinski M, Eizaguirre C (In press) A field reciprocal transplant experiment reveals asymmetric costs of migration between lake and river ecotypes of three-spined sticklebacks (Gasterosteus aculeatus). Journal of Evolutionary Biology.

2016:


Lenz TL, Spirin V, Jordan DM, Sunyaev SR (2016) Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection. Molecular Biology and Evolution 33: 2555-2564.

 

Savova V, Chun SG, Sohail M, McCole R, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA (2016) Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nature Genetics 48: 231-237.

 

Huang Y, Chain FJJ, Panchal M, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TBH, Milinski M, Feulner, PGD (2016) Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks. Molecular Ecology 25: 943-958.

2015:


McLaren PJ*, Coulonges C*, Bartha I*, Lenz TL, Deutsch AJ, Bashirova A, Buchbinder S, Carrington M, Cossarizza A, Dalmau J, De Luca A, Goedert JJ, Gurdasani D, Haas DW, Herbeck JT, Johnson EO, Kirk GD, Lambotte O, Luo M, Mallal S, van Manen D, Martinez-Picado J, Meyer L, Miro J, Mullins JI, Obel N, Poli G, Sandhu M, Schuitemaker H, Shea P, Theodorou I, Walker BD, Weintrob A, Winkler C, Wolinsky SM, Raychaudhuri S, Goldstein DB, Telenti A, de Bakker PIW, Zagury J-F, Fellay J (2015) Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proceedings of the National Academy of Sciences of the United States of America 112: 14658-14663.

 

Lenz TL (2015) Transcription in space - Environmental vs. genetic effects on differential immune gene expression [Perspective]. Molecular Ecology 24: 4583-4585.

 

Lenz TL*, Deutsch AJ*, Han B, Hu X, Okada Y, Eyre S, Knapp M, Zhernakova A, Huizinga TWJ, Abecasis G, Becker J, Boeckxstaens, GE, Chen W-M, Franke A, Gladman DD, Gockel I, Gutierrez-Achury J, Martin J, Nair RP, Nöthen MM, Onengut-Gumuscu S, Rahman P, Rantapää-Dahlqvist S, Stuart PE, Tsoi LC, Van Heel DA, Worthington J, Wouters MM, Klareskog L, Elder JT, Gregersen P, Schumacher J, Rich SS, Wijmenga C, Sunyaev SR, de Bakker PIW, Raychaudhuri S (2015) Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nature Genetics 47: 1085-1090. * equal contribution

 

Hu X*, Deutsch AJ*, Lenz TL, Onengut-Gumuscu S, Han B, Chen W-M, Howson JM, Todd JA, de Bakker PIW, Rich SS, Raychaudhuri S (2015) Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nature Genetics 47: 898-905.

 

Feulner PGD, Chain FJJ, Panchal M, Huang Y, Eizaguirre C, Kalbe M, Lenz TL, Samonte IE, Stoll M, Bornberg-Bauer E, Reusch TBH, Milinski M (2015) Genomics of divergence along a continuum of parapatric population differentiation. PLoS Genetics 11: e1004966.

 

Kaufmann J, Eizaguirre C, Milinski M, Lenz TL (2015) The contribution of post-copulatory mechanisms to incipient ecological speciation in sticklebacks. Biology Letters 11: 20140933.

2014:


Chain FJJ, Feulner PGD, Panchal M, Eizaguirre C, Samonte IE, Kalbe M, Lenz TL, Stoll M, Bornberg-Bauer E, Milinski M, Reusch TBH (2014) Extensive copy-number variation of young genes across stickleback populations. PLoS Genetics 10: e1004830.

 

Kaufmann J, Lenz TL, Milinski M, Eizaguirre C (2014) Experimental parasite infection reveals costs and benefits of paternal effects. Ecology Letters 17: 1409-1417.

2013:


Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Yim SH, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN (2013) Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii. Nature Communications 4: 2212.

 

Lenz TL, Eizaguirre C, Kalbe M, Milinski M (2013) Evaluating patterns of convergent evolution and trans-species polymorphism at MHC immunogenes in two sympatric stickleback species. Evolution 67: 2400-2412.

 


Lenz TL, Mueller B, Trillmich F, Wolf JBW (2013) Divergent allele advantage at MHC-DRB through direct and maternal genotypic effects and its consequences for allele pool composition and mating. Proceedings of the Royal Society: B 280: 20130714. Featured on the cover:

 

Lenz TL, Eizaguirre C, Rotter B, Kalbe M, Milinski M (2013) Exploring local immunological adaptation of two stickleback ecotypes by experimental infection and transcriptome-wide digital gene expression analysis. Molecular Ecology 22: 774-786.

 

Feulner PGD, Chain FJJ, Panchal M, Eizaguirre C, Kalbe M, Lenz TL, Mundry M, Samonte IE, Stoll M, Milinski M, Reusch TBH, Bornberg-Bauer E (2013) Genome-wide patterns of standing genetic variation in a marine population of three-spined sticklebacks. Molecular Ecology 22: 635-649.

2012:


Eizaguirre C*, Lenz TL*, Kalbe M, Milinski M (2012) Divergent selection on locally adapted MHC immune genes experimentally proven in the field. Ecology Letters 15: 723-731. * equal contribution

 

Eizaguirre C, Lenz TL, Kalbe M, Milinski M (2012) Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations. Nature Communications 3:621.

2011


Samonte-Padilla IE, Eizaguirre C, Scharsack JP, Lenz TL, Milinski M (2011) Induction of diploid gynogenesis in an evolutionary model system, the three-spined stickleback (Gasterosteus aculeatus). BMC Developmental Biology 11: 55.

 

Lenz TL (2011) Computational prediction of MHC II-antigen binding supports divergent allele advantage and explains trans-species polymorphism. Evolution 65: 2380-2390.

 

Lenz TL (2011) Uterine selection for immunocompetent offspring [Letter]. Proceedings of the National Academy of Sciences of the United States of America 108: E253.

 

Eizaguirre C, Lenz TL, Sommerfeld RD, Harrod C, Kalbe M, Milinski M (2011) Parasite diversity, patterns of MHC II variation and olfactory based mate choice in diverging three-spined stickleback ecotypes. Evolutionary Ecology 25: 605-622.

2010


Eizaguirre C, Lenz TL (2010) Major histocompatibility complex polymorphism: dynamics and consequences of parasite-mediated local adaptation in fishes. Journal of Fish Biology 77: 2023-2047.

2009


Lenz TL, Eizaguirre C, Scharsack JP, Kalbe M, Milinski M (2009) Disentangling the role of MHC-dependent 'good genes' and 'compatible genes' in mate choice decisions of three-spined sticklebacks under semi-natural conditions. Journal of Fish Biology (special stickleback issue) 75: 2122 - 2142.

 

Lenz TL, Wells K, Pfeiffer M, Sommer S (2009) Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus). BMC Evolutionary Biology 9: 269.

 

Eizaguirre C, Yeates SE, Lenz TL, Kalbe M, Milinski M (2009) MHC-based mate choice combines good genes and maintenance of MHC polymorphism. Molecular Ecology 18: 3316-3329.

 

Lenz TL, Eizaguirre C, Becker S, Reusch TBH (2009) RSCA genotyping of MHC for high-throughput evolutionary studies in the model organism three-spined stickleback Gasterosteus aculeatus. BMC Evolutionary Biology 9: 57.

 

Eizaguirre C, Lenz TL, Traulsen A, Milinski M (2009) Speciation accelerated and stabilized by pleiotropic major histocompatibility complex immunogenes. Ecology Letters 12: 5-12.

2008


Lenz TL, Becker, S (2008) Simple approach to reduce PCR artefact formation leads to reliable genotyping of MHC and other highly polymorphic loci - implications for evolutionary analysis. Gene 427: 117-123.

2007


Urbach D, Bittner D, Lenz TL, Bernet D, Wahli T, Wedekind C (2007) Sperm velocity in an Alpine whitefish: effects of age, size, condition, fluctuating asymmetry and gonad abnormalities. Journal of Fish Biology 71: 672-683.

 

Lenz TL, Jacob A., Wedekind C (2007) Manipulating sex ratio to increase population growth: the example of the Lesser Kestrel. Animal Conservation 10: 236-244.


Meetings / Seminars


2017:

Zoological institute, Department of Biology, University of Hamburg, Germany. 28.02.
Invited seminar: Evolutionary genomics of the adaptive immune system in vertebrates.

 

BRC, Hungarian Academy of Science. Szeged, Hungary. 07.02.
Invited seminar: Evolutionary genomics of an optimal adaptive immune response.


2016:

IRI Symposium on Evolutionary Medicine. Berlin, Germany. 10.11.
Invited speaker: Evolutionary genomics of an optimal adaptive immune response.

 

Annual meeting of the German Zoological Society. Kiel, Germany. 14.-17.09.
Invited section speaker: Evolutionary genetics and genomics of the adaptive immune system.

 

Max Planck Institute for the Science of Human History, Jena, Germany. 30.03.
Invited seminar: Evolutionary genomics of an optimal adaptive immune response.

 

German American Frontiers of Science (GAFOS-Kavli) meeting by the US National Academy of Science and the Alexander v. Humboldt Foundation, Potsdam, Germany. 10.-13.03.
Invited speaker: Evolution of an optimal immune response.

 

Institute for Neuro- and Bioinformatics, University of Luebeck, Germany. 05.02.
Invited seminar: Evolutionary genomics of an optimal adaptive immune response.

 

Bioinformatics Network, University of Kiel, Germany. 15.01.
Invited seminar: Evolutionary genomics of an optimal adaptive immune response.


2015:

Annual Conference of the German Society for Immunogenetics. Luebeck, Germany. 8.-10.10.
Plenary Talk: Choosing the optimal partner: Evolutionary implications of immunogenetic diversity.

 

International Conference of the Society for Molecular Biology and Evolution. Vienna, Austria. 12.-16.07.
Talk: Evolutionary dynamics of an optimal adaptive immune response.  Featured by Alex Cagan (@ATJCagan)

 

Zoological institute, Department of Biology, Hamburg University, Germany. 18.06.
Invited seminar: Immune gene evolution and local immunogenetic adaptation in vertebrates.

 

Department of Biology, Lund University, Sweden. 12.06.
Guest lecture: Evolutionary genetics of the adaptive immune system.

 

Inaugural meeting of the International Society for Evolution, Medicine and Public Health. Tempe, USA. 18.-21.03.
Talk: Non-additive effects of HLA genes in four common autoimmune diseases - The ghost of selection past?

 

Department of Animal Ecology and EBC Graduate School, Uppsala University, Sweden. 17.02.
Invited seminar: Evolutionary genetics of the adaptive immune system.

 

Department of Animal Behavior, University of Bielefeld, Germany. 14.01.
Invited seminar: Host-parasite coevolution and adaptive immunity - From sequence evolution to mate choice.


2014:

Jacques Monod Conference 'Infectious diseases as drivers of evolution: the challenge ahead'. Roscoff, France. 06.-10.09.
Talk: Costs and benefits of parasite-mediated balancing selection: The example of the MHC.


2013:

International Conference of the Society for Molecular Biology and Evolution. Chicago, USA. 07.-11.07.
Talk: Costs and benefits of balancing selection: The example of the MHC.


2012:

Evolutionary Genomics Supergroup Retreat. Broad Institute, Cambridge, USA. 07.12.
Chalk talk: Indirect costs of balancing selection: The example of the major histocompatibility complex (MHC).

 

Annual meeting of the American Society of Human Genetics. San Francisco, USA. 06.-10.11.
Poster: Balancing selection may prevent purging of deleterious mutations and explain some of the frequently observed MHC-disease associations.

 

Nature Genetics Conference on Genomics of Common Diseases. Bethesda, USA. 19.-22.09.
Poster: Balancing selection may prevent purging of deleterious mutations and explain some of the frequently observed MHC-disease associations.

 

Department of Ecology and Evolution. Stony Brook University. New York, USA. 25.04.
Invited seminar: Immune gene evolution and local immunogenetic adaptation in vertebrates.


2011:

Aquavit Symposium. MPI for Evolutionary Biology, Plön, Germany. 30.3.-01.04.
Talk: Cryptic female choice for optimal MHC diversity?.


2010:

International Conference of the Society for Molecular Biology and Evolution. Lyon, France. 04.-08.07.
Poster: Computational prediction of HLA-antigen binding explains divergent HLA genotypes and the maintenance of ancient allelic lineages.

 

Aquavit Symposium. MPI for Evolutionary Biology, Plön, Germany. 14.-15.05.
Talk: A computational approach to understanding the maintenance of MHC diversity.


2009:

International Conference on Evolutionary Ecology of Fishes. Erkner, Germany. 22.-25.11.
Talk: Evolution of adaptive immune genes in two sympatric stickleback species (G. aculeatus & P. pungitius).

 

Workshop 'Mind the gap: Joining theoretical and empirical populations genetics'. Freiburg, Germany. 02.-03.10.
Talk: Parallel evolution of adaptive immune genes in two sympatric stickleback species (G. aculeatus & P. pungitius).

 

International Conference of the European Society for Evolutionary Biology. Torino, Italy. 24.-29.08.
Poster: Digital analysis of adaptive gene expression in two different ecotypes of the three-spined stickleback.

 

International Conference on Stickleback Behaviour and Evolution. Leicester, UK, 13.-17.07.
Talk: Disentangling the role of MHC-dependent 'good genes' and 'compatible genes' in mate choice decisions of three-spined sticklebacks under semi-natural conditions.

 

Aquavit Symposium. MPI for Evolutionary Biology, Plön, Germany. 14.-15.05.
Talk: Effects of MHC diversity and specific haplotypes on immunocompetence, reproductive success and mate choice decisions of three-spined sticklebacks under semi-natural conditions.

 

Workshop of the German Genetics Society. Evolutionary Genetics: Impact of Next Generation Sequencing Technologies. Wittenberg, Germany, 02.-04.04.
Talk: Digital analysis of adaptive gene expression in two different ecotypes of the three-spined stickleback.


2008:

Aquavit Symposium. MPI for Evolutionary Biology, Plön, Germany. 22.-23.05.
Talk: Stickleback goes 454.

 

PhD workshop of the German Zoological Society. University of Hamburg, Germany. 22.-24.02.
Poster: Evolution of adaptive immune genes in two sympatric stickleback species


2007:

International Conference of the European Society for Evolutionary Biology. Uppsala, Sweden. 20.-25.08.
Poster: Evolution of adaptive immune genes in two sympatric stickleback species.

 

Group of Prof. C. Wedekind, Department of Ecology and Evolution, University of Lausanne, Switzerland. 30.05.
Invited seminar: Evolutionary Ecology of the Stickleback.

 

Aquavit Symposium. MPI for Limnology, Plön, Germany. 08.-09.03.
Talk: Same same but different - 'Ecolution' of two stickleback species.


2006:

International Conference on Stickleback Behavior and Evolution. UAA, Anchorage, USA. 30.07.-04.08.06.
Talk: RSCA - a reliable method to type highly variable loci.

 

Aquavit Symposium. MPI for Limnology, Plön, Germany. 07.-08.03.
Talk: Molecular Depths of MHC - The quest is continuing.

 

PhD workshop of the German Zoological Society: University of Potsdam, Germany. 24.-26.02.
Talk: The house finch, an epidemic and a bottleneck - effects on MHC diversity.


2005:

International Conference of the European Society for Evolutionary Biology. Krakow, Poland. 15.-20.08.
Poster: The genetic effect of manipulating sex ration in the captive breeding of lesser kestrel (Falco naumanni).